乙型肝炎重症化（第1、2卷）英文版 pdf 下载 txt 阿里云 lit rtf azw3 免费

This book assembles recent achievements in both basic research and clinical management in the field of hepatology, virology, and immunology. It provides up-to-date information for clinicians who can apply the relevant knowledge to their daily clinical practice and for researchers who are interested in clinically orientated studies. The updated and detailed technology and state-of-the-art treatment strategies provided in this book serve as references for clinicians and resident physicians in the daily management of ACLF.The rationality and strategies for basic research as well as patient management in this book can also be a valuable reference for other fatal and end-stage liver diseases than HBV-induced ACLF.

This Volume 1 has six chapters and focuses on the definition, research technology, virology, genetics, and immunology.

本书汇集了在肝病、病毒学和免疫学领域的基础研究和临床领域的新成果。它为临床医师提供了新的信息，临床医师可以将相关知识应用于日常临床实践，也为对临床导向研究感兴趣的研究人员提供了新的信息。本书所提供的新和详细的技术和先进的治疗策略为临床医生和住院医师对乙型重型肝炎患者的日常管理提供参考。本书对基础研究和患者管理的合理性和策略，对其他重型肝炎和晚期肝病，如乙型肝炎病毒诱导的肝衰竭，也有一定的参考价值。

*卷共分六章，重点介绍了乙型肝炎重症化的定义、研究技术、病毒学、遗传学和免疫学。

1 Introduction to Acute Exacerbation of Chronic

Hepatitis B (AECHB) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1

Qin Ning, Di Wu, Wei Guo, Wei-Na Li, Xiao-Jing Wang, and Ke Ma

2 Research Methods and Techniques for Acute Exacerbation of

Chronic Hepatitis B . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49

Zhi Chen, Dong Xu, Tao Chen, Dao-Feng Yang, and Yi-Min Mao

3 Virological Factors Involved in AECHB . . . . . . . . . . . . . . . . . . . . . . . . . . 119

Hong Tang, Mei-Fang Han, and Yi-Ming Zhang

4 Host Genetic Characters of Acute Exacerbation of

Chronic Hepatitis B (AECHB). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 159

Yu-Ming Wang, Jun-Qi Niu, Guo-Hong Deng, and Ying-Ren Zhao

5 Immunological Features of AECHB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 223

Ping Lei, Guan-Xin Shen, Fu-Sheng Wang, Qin Ning, Hong Ren,

Wei-Ming Yan, and Di Wu

6 Other Precipitating Factors for AECHB . . . . . . . . . . . . . . . . . . . . . . . . . 315

Bao-Hong Wang, Jing Guo, Lan-Juan Li, Tao Chen, Chun-Xia Guo,

and Yong-Wen He1 Clinical Manifestations and Laboratory Tests of AECHB

and Severe Hepatitis (Liver Failure) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1

Liang Peng, Zhi-Liang Gao, Yu-Ming Wang, Deng-Ming He,

Jin-Ming Zhao, Xue-Fan Bai, and Xiao-Jing Wang

2 Main Complications of AECHB and Severe

Hepatitis B (Liver Failure) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 91

Jian-Xin Song, Lin Zhu, Chuan-Long Zhu, Jin-Hua Hu, Zijian Sun,

Xiang Xu, Min-You Xin, Qiong-Fang Zhang, Da-Zhi Zhang,

Jia Shang, Jia-Quan Huang, and Dong Xu

3 Early Prognostic Predictive System of AECHB

and the Diagnosis of Severe Hepatitis B (Liver Failure) . . . . . . . . . . . . . 227

Zhi Chen, Qin Ning, and Guang Chen

4 Treatment of AECHB and Severe Hepatitis (Liver Failure) . . . . . . . . . . 273

Yu-Ming Wang, Ke Li, Xiao-Guang Dou, Han Bai, Xi-Ping Zhao,

Xiong Ma, Lan-Juan Li, Zhi-Shui Chen, and Yuan-Cheng Huang

5 Antiviral Therapy for AECHB and Severe

Hepatitis B (Liver Failure) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 371

Qin Ning, Ting Wu, Hai-Bing Su, Ke Ma, Jun-Ying Qi,

Ming Ni, and Di Wu

6 Prognosis, Prevention and Research Prospects

of Progression to Severe Hepatitis B (Liver Failure) . . . . . . . . . . . . . . . . 457

Yu-Ming Wang, Dao-Feng Yang, Ming Wang, Nazia Selzner, Kaveh

Farrokhi, Andrzej Chruscinski, and Gary Levy

宁琴教授为传染病学、免疫学教授，传染病学主任医师，博士生导师，国家杰出青年科学基金获得者（2002年）,科技部973重大传染病专项首席科学家（2007年），国家十二五/十三五传染病重大专项牵头人（2013/2017年），*“长江学者和创新团队发展计划”创新团队牵头人（2012年），享受国务院政府特殊津贴专家，卫生部有突出贡献中青年专家，华中科技大学华中学者“领军岗”（2012年）。为华中科技大学首批受聘国家二级教授。现任华中科技大学同济医学院附属同济医院传染病学教研室主任、感染科主任、感染性疾病研究所所长。获 “湖北省青年岗位能手”称号、“湖北省青年科技奖”和“上海宝钢教育奖”（优秀教师）、武汉市“十大杰出青年”和武汉市“三八红旗手标兵”称号。宁琴教授主要从事肝脏疾病包括慢性病毒性肝炎、脂肪肝、肝纤维化、重型肝炎和肝癌的基础研究与临床、教学工作近30年。近年来发表论文300余篇，其中SCI论文276篇，被引2553次（他引1933）（2018年5月），包括JCI， J Immunology, JBC, Human Gene Therapy，Liver International, Journal of Hepatology, Antiviral Therapy，Biol Chem等。发明专利6项。

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This book assembles recent achievements in both basic research and clinical man_x005f_x005f_x005fagement in the field of hepatology, virology, and immunology. It provides up-todate information for clinicians who can apply the relevant knowledge to their daily clinical practice and for researchers who are interested in clinically orientated studies. The updated and detailed technology and state-of-the-art treatment strategies provided in this book serve as references for clinicians and resident physicians in the daily management of ACLF.?The rationality and strategies for basic research as well as patient management in this book can also be a valuable reference for other fatal and end-stage liver diseases than HBV-induced ACLF.This Volume 1 has six chapters and focuses on the definition, research technology, virology, genetics, and immunology.

前言

It is now recognized that as a consequence of chronic HBV infection, many patients

with or without established cirrhosis will develop acute decompensation and multi_x005forgan failure, a syndrome known as acute-on-chronic liver failure (ACLF). Once

patients develop ACLF, they are at high risk of death. A number of triggers including reactivation of HBV, coinfection of hepatitis A or E virus, onset of bacterial

infection, gastrointestinal bleeding and development of renal dysfunction can precipitate the development of ACLF in patients who have been previously stable.

ACLF is prevalent in Asia where many patients have incubative chronic hepatitis B

virus (HBV) infection.

For the past decade, with an increasing understanding of the disease mechanisms

and improved general internal medications, the overall mortality has significantly

decreased due to HBV infection-related ACLF (HBV-ACLF) in Chinese patients.

Here we have assembled a group of hepatologists and scientists from academic

hospitals and universities to explore the current understanding of the clinical,

genetic, virologic and immunologic factors that contribute to ACLF. In this book of

12 chapters, we have explored the current state of knowledge of HBV infection with

a specific focus on the natural history and the clinical course to define important

host and viral factors to the development of ACLF, sharing our profound experience

and clinical procedures in early diagnosis and treatment of HBV-ACLF patients and

its complications. All together about 2649 references have been cited, of which 754

were since 2012. At the beginning of the book, there is a complete table of contents,

which together with the general index makes it possible for the reader to find specific topics easily. In each chapter, there is an abstract for the reader to gain a quick

information of the chapter. We have also used 55 coloured figures to make the illus_x0002_trations even more visual.

We enlisted the helpful advice of friends, colleagues and senior experts to supplement or confirm our own interpretations. The contacts arising from these discussions have been immensely benignant to me. Here my special thanks to Prof. Gary

Levy, Prof. Didier Samuel, Prof. Gyongyi Szabo, Prof. Lanjuan Li, Prof. Zhimeng

Lu, Prof. Shiv Kumar Sarin, Prof. Stephen Locarnini, Prof. Xinhua Weng, Prof.

Yuquan Wei and Prof. Hui Zhuang.

Finally I should express my gratitude to the employees at HUST Press and

Springer Publishing House (Mr. James Hu) for their professional help in completing

this book, especially to Ms. Lian-Di Wang, senior editor, and Mr. Wei Che, projector manager, who gave their kind support at all times.